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KMID : 0616619980040010167
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Journal of Soonchunhyang Medical College
1998 Volume.4 No. 1 p.167 ~ p.176
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Effects of Minoxidil and Griseofulvin on the growth of fbroblasts
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Abstract
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Fibroblasts are known as the key cells for wound contraction. In the plastic surgical field, wound contraction is one of the main concerns. Many drugs and treatment modalities have been tried to reduce the action of the fibroblasts. To investigate the effects of minoxidil and griseofulvin on fibroblasts, fetal human fibroblasts were isolated from the anterior chest of normal individual. Minoxidil, in addition to its effect on hypertention and hair growth and griseofulvin which has been used as antifungal agent were added on cultured fibroblasts. The morphological changes and numerical changes of the fibroblasts were obseved by phase contrast microscopy. In low concentration, minoxidil do not affect the fibroblast proliferation but in high concentration, it inhibt fibroblast proliferation and changes morphology of fibroblasts. Griseofulvin affects the fibroblasts but not so significant as minoxidil.
The significance of present findings is possible usage of this drugs to treat clinical fibrosis, hypertrophic scars. Futher studies are planned to learn more about a possible role for minoxidil and griseofulvin in prevention of wound contraction.
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